Cell-Free DNA and DNase Activity in Dogs with Immune-Mediated Hemolytic Anemia
نویسندگان
چکیده
منابع مشابه
Cell‐Free DNA and DNase Activity in Dogs with Immune‐Mediated Hemolytic Anemia
BACKGROUND Immune-mediated hemolytic anemia (IMHA) in dogs has a high risk of thrombosis and is associated with marked neutrophilia and necrosis. Cell death and release of neutrophil extracellular traps contribute to increased serum concentrations of cell-free DNA, and in human autoimmune disease reduced DNase activity further increases cell-free DNA. Free DNA in blood has prothrombotic propert...
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BACKGROUND Studies of some human prothrombotic diseases suggest that phosphatidylserine-positive (PS+) and tissue factor-positive (TF+) microparticles (MPs) might play a role in the pathogenesis of thrombosis or serve as biomarkers of thrombotic risk. HYPOTHESIS/OBJECTIVES To determine if circulating levels of PS+MP and procoagulant activity (PCA) associated with PS+MPs and TF+ MPs are increa...
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s and Unpublished Data: a. Garcia-Pereira BL, Jutkowitz LA, McBride BL, Brown AJ. Prevalence of portal vein thrombosis and pulmonary thromboembolism in dogs with immune-mediated hemolytic anemia. J Vet Emerg Crit Care 2009;19:A8 (abstract). b. McBride BL, Jutkowitz LA, Garcia-Pereira BL. Association between length of storage of transfused red blood cells (RBCs) and outcome in dogs with immune-m...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2017
ISSN: 0891-6640
DOI: 10.1111/jvim.14808